Providing guests with bicycle rentals, Palazzo Castromediano Lecce hotel is located approximately 15 minutes on foot from Railway Museum of Puglia.

The accommodation is situated about 50 km from Casale airport and adjacent to Church of Saint Matthew. The property is only 1.4 km from Foresta Urbana di Lecce Nature Preserve and just 5 minutes' walk from Museo Faggiano. Parco di Belloluogo can also be found a short distance from the hotel. Guests will find Porta San Biagio bus stop next to the accommodation, merely 300 metres away.

Located a short walk from the 3-star Palazzo Castromediano hotel, the seafood restaurant Il Convitto o Al Convitto offers an Italian menu.